Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC030
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-29 08:43
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3/4+1/4+1/2+1/4 caps Madopar HBS a 125mg 2 uvece New patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 15 individuals with a value less than 0.56 were subsequently diagnosed with PD. That is, 35.71% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.56 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 33, 'TN': 25, 'TP': 9, 'FP': 5}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 41, 'TN': 30, 'TP': 1, 'FP': 0}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 24.748
timePerCircleCoV 0.564751
timePerCircleSlope -0.111426
meanError 1.77052
tremorFreq 5.46875
tremorRelPower 33.6812
tremorGyroAmpMean 0.0361533
tremorGyroAmpSlope 0.00124818
tremorGyroAmpCoV 0.390188
tremorCoordAmpMean 0.0411542
tremorCoordAmpSlope 0.000933293
tremorCoordAmpCoV 0.362081
tremorAccAmpMean 0.0390844
tremorAccAmpSlope 0.00134627
tremorAccAmpCoV 0.419116
tremorPcRelVar 0.642642
tremorPcX -0.85438
tremorPcY 0.519648

Circle Segment 1

Duration 38.88 s, Accuracy Estimate 2.288 (lower is better)

Circle Segment 2

Duration 58.36 s, Accuracy Estimate 2.305 (lower is better)

Circle Segment 3

Duration 26.72 s, Accuracy Estimate 1.285 (lower is better)

Circle Segment 4

Duration 16.24 s, Accuracy Estimate 1.807 (lower is better)

Circle Segment 5

Duration 13.8 s, Accuracy Estimate 1.648 (lower is better)

Circle Segment 6

Duration 13.04 s, Accuracy Estimate 1.631 (lower is better)

Circle Segment 7

Duration 19.64 s, Accuracy Estimate 1.317 (lower is better)

Circle Segment 8

Duration 20.96 s, Accuracy Estimate 1.644 (lower is better)

Circle Segment 9

Duration 17.88 s, Accuracy Estimate 1.297 (lower is better)

Circle Segment 10

Duration 21.96 s, Accuracy Estimate 2.483 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 46.0267
timePerSpiralCoV 0.169529
timePerSpiralSlope -0.0612316
meanError 2.01373
tremorFreq 6.34766
tremorRelPower 33.2487
tremorGyroAmpMean 0.0404208
tremorGyroAmpSlope 0.000958878
tremorGyroAmpCoV 0.429842
tremorCoordAmpMean 0.0559232
tremorCoordAmpSlope 8.53941e-05
tremorCoordAmpCoV 0.685524
tremorAccAmpMean 0.0620071
tremorAccAmpSlope 0.000335223
tremorAccAmpCoV 0.207762
tremorPcRelVar 0.602952
tremorPcX -0.678123
tremorPcY -0.734949

Spiral Segment 1

Duration 61.68 s, Accuracy Estimate 1.932 (lower is better)

Spiral Segment 2

Duration 43.12 s, Accuracy Estimate 2.041 (lower is better)

Spiral Segment 3

Duration 42.56 s, Accuracy Estimate 1.946 (lower is better)

Spiral Segment 4

Duration 43.0 s, Accuracy Estimate 1.949 (lower is better)

Spiral Segment 5

Duration 45.16 s, Accuracy Estimate 2.142 (lower is better)

Spiral Segment 6

Duration 40.64 s, Accuracy Estimate 2.073 (lower is better)

Elel

eDurationMean 0.84425
eDurationStd 0.231527
eDurationStdnorm 0.274239
eDurationMedian 0.7925
eDurationQuartdelta 0.205
eDurationQuartdeltanorm 0.258675
eDurationKurt 5.00909
eDurationTrenddiff -0.1975
eDurationTrendratio 0.785908
eWidthMean 3.27308
eWidthStd 0.799915
eWidthStdnorm 0.244393
eWidthMedian 3.1005
eWidthQuartdelta 0.9945
eWidthQuartdeltanorm 0.320755
eWidthKurt 3.92472
eWidthTrenddiff -0.0585
eWidthTrendratio 0.981481
eHeightMean 8.39768
eHeightStd 2.00026
eHeightStdnorm 0.238192
eHeightMedian 8.19
eHeightQuartdelta 2.3985
eHeightQuartdeltanorm 0.292857
eHeightKurt 3.30203
eHeightTrenddiff -1.755
eHeightTrendratio 0.806452
eAspectMean 0.396759
eAspectStd 0.0817974
eAspectStdnorm 0.206164
eAspectMedian 0.391975
eAspectQuartdelta 0.118376
eAspectQuartdeltanorm 0.301997
eAspectKurt 3.09119
eAspectTrenddiff 0.0676836
eAspectTrendratio 1.1946
eSlantMean -0.230502
eSlantStd 0.13751
eSlantStdnorm -0.596568
eSlantMedian -0.217361
eSlantQuartdelta 0.141472
eSlantQuartdeltanorm -0.650863
eSlantKurt 3.98959
eSlantTrenddiff 0.035739
eRtopMean 0.502759
eRtopStd 0.184098
eRtopStdnorm 0.366175
eRtopMedian 0.535
eRtopQuartdelta 0.260073
eRtopQuartdeltanorm 0.486118
eRtopKurt 2.37795
eRtopTrenddiff 0.219302
eRbotMean 1.13729
eRbotStd 0.309779
eRbotStdnorm 0.272384
eRbotMedian 1.06905
eRbotQuartdelta 0.335674
eRbotQuartdeltanorm 0.313993
eRbotKurt 3.35632
eRbotTrenddiff -0.017033
eRrightMean 0.767853
eRrightStd 0.106287
eRrightStdnorm 0.138421
eRrightMedian 0.772118
eRrightQuartdelta 0.14198
eRrightQuartdeltanorm 0.183884
eRrightKurt 3.31158
eRrightTrenddiff 0.0853643
eRleftMean 0.558933
eRleftStd 0.133748
eRleftStdnorm 0.239292
eRleftMedian 0.532293
eRleftQuartdelta 0.172945
eRleftQuartdeltanorm 0.324905
eRleftKurt 3.30886
eRleftTrenddiff -0.103838
lDurationMean 1.12359
lDurationStd 0.292766
lDurationStdnorm 0.260563
lDurationMedian 1.135
lDurationQuartdelta 0.295
lDurationQuartdeltanorm 0.259912
lDurationKurt 4.08408
lDurationTrenddiff -0.275
lDurationTrendratio 0.780876
lWidthMean 4.632
lWidthStd 1.84285
lWidthStdnorm 0.397853
lWidthMedian 4.329
lWidthQuartdelta 1.60875
lWidthQuartdeltanorm 0.371622
lWidthKurt 7.21547
lWidthTrenddiff -0.351
lWidthTrendratio 0.925
lHeightMean 22.119
lHeightStd 5.88211
lHeightStdnorm 0.26593
lHeightMedian 20.358
lHeightQuartdelta 6.40575
lHeightQuartdeltanorm 0.314655
lHeightKurt 4.44972
lHeightTrenddiff -6.435
lHeightTrendratio 0.742991
lAspectMean 0.211884
lAspectStd 0.0654072
lAspectStdnorm 0.308693
lAspectMedian 0.200935
lAspectQuartdelta 0.0880818
lAspectQuartdeltanorm 0.438361
lAspectKurt 3.45283
lAspectTrenddiff 0.0212185
lAspectTrendratio 1.10802
lSlantMean -0.103081
lSlantStd 0.106024
lSlantStdnorm -1.02855
lSlantMedian -0.0972973
lSlantQuartdelta 0.102571
lSlantQuartdeltanorm -1.0542
lSlantKurt 3.46618
lSlantTrenddiff -0.0426441
lRtopMean 0.507785
lRtopStd 0.207358
lRtopStdnorm 0.408358
lRtopMedian 0.522727
lRtopQuartdelta 0.361286
lRtopQuartdeltanorm 0.691157
lRtopKurt 1.86911
lRtopTrenddiff 0.0919913
lRbotMean 1.1064
lRbotStd 0.493741
lRbotStdnorm 0.446258
lRbotMedian 1
lRbotQuartdelta 0.496797
lRbotQuartdeltanorm 0.496797
lRbotKurt 6.13833
lRbotTrenddiff 0.0751634
lRrightMean 0.748573
lRrightStd 0.106446
lRrightStdnorm 0.142198
lRrightMedian 0.758621
lRrightQuartdelta 0.137712
lRrightQuartdeltanorm 0.181529
lRrightKurt 2.47816
lRrightTrenddiff 0.0724257
lRleftMean 0.530088
lRleftStd 0.245769
lRleftStdnorm 0.463639
lRleftMedian 0.480916
lRleftQuartdelta 0.446184
lRleftQuartdeltanorm 0.927779
lRleftKurt 1.64494
lRleftTrenddiff -0.00984304

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.995517
sumTouchScores 21.9014
meanMovementTime 0.79619
numTouches 22
undershootPercentage 0
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.903396
sumTouchScores 15.3577
meanMovementTime 1.12875
numTouches 17
undershootPercentage 0
overshootPercentage 23.5294

ZigZag

numZigzags 5
timePerZigzagMean 30.728
timePerZigzagCoV 0.540967
timePerZigzagSlope -0.297318
meanError 2.25029
tremorFreq 6.54297
tremorRelPower 32.9339
tremorGyroAmpMean 0.0359309
tremorGyroAmpSlope -0.000631582
tremorGyroAmpCoV 0.406242
tremorCoordAmpMean 0.101407
tremorCoordAmpSlope 0.00898086
tremorCoordAmpCoV 0.913401
tremorAccAmpMean 0.0451667
tremorAccAmpSlope 0.0040607
tremorAccAmpCoV 0.314523
tremorPcRelVar 0.808743
tremorPcX 0.00441409
tremorPcY -0.99999

ZigZag Segment 1

Duration 59.16 s, Accuracy Estimate 2.501 (lower is better)

ZigZag Segment 2

Duration 31.64 s, Accuracy Estimate 2.076 (lower is better)

ZigZag Segment 3

Duration 23.16 s, Accuracy Estimate 1.947 (lower is better)

ZigZag Segment 4

Duration 20.76 s, Accuracy Estimate 2.233 (lower is better)

ZigZag Segment 5

Duration 18.92 s, Accuracy Estimate 2.495 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 13.96
timePerZigzagCoV 0.294621
timePerZigzagSlope -0.125215
zigzagHeightMean 72.4155
zigzagHeightCoV 0.0511683
zigzagHeightSlope -0.0304081
meanError 0.0383669
tremorFreq 6.25
tremorRelPower 28.4133
tremorGyroAmpMean 0.0479715
tremorGyroAmpSlope -0.00722215
tremorGyroAmpCoV 0.342787
tremorCoordAmpMean 0.225337
tremorCoordAmpSlope 0.00160936
tremorCoordAmpCoV 1.01775
tremorAccAmpMean 0.10715
tremorAccAmpSlope -0.000697172
tremorAccAmpCoV 0.17312
tremorPcRelVar 0.898418
tremorPcX -0.0706378
tremorPcY 0.997502

ZigZag Offset Segment 1

Duration 21.24 s, Accuracy Estimate 0.046 (lower is better)

ZigZag Offset Segment 2

Duration 12.2 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 3

Duration 11.28 s, Accuracy Estimate 0.035 (lower is better)

ZigZag Offset Segment 4

Duration 12.96 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 5

Duration 12.12 s, Accuracy Estimate 0.048 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.77}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.56}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.9741586730746348}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9287834250551492}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5664118133096921}